Source: dc.wikia.com
2. Mr. Terrific
Iron Man went up against Kree Armadas. He fought Thanos. He stood proud against Galactus. But at the end of the day, you can’t fight what you can’t see.
Mr. Terrific is the third-smartest man in the DC Universe (check our smartest superheroes list). That’s pretty friggin’ smart. And his T-Spheres and mask give him tons of special abilities. Primarily, he’s able to become invisible to technology. No matter how good Tony’s scanners are, they still can’t pick up Mr. Terrific. In order to fight him, he’d have to pop open that mask of his, and therefore lose all the scanners and feedback he’d normally have right in front of him.
Essentially, it would be a toss up between fighting with none of his tech easily at his disposal and fighting without the ability to see his opponent, and neither is a good option. And when you have two geniuses fighting, always bet on the one who’s able to use all of his tools.
Tony’s playing with a massive handicap here.

