Source: screenrant.com

7. Mr. Hyde

Drug of Choice: Hyde Formula

Calvin Zabo is a brilliant researcher who’s obsessed with the Strange Case of Dr. Jekyll and Mr. Hyde. I'm sure you can guess where this is going.

He purposely creates a formula that turns him into a hulking behemoth made of muscles and evil, tries to murder Thor, and fails. Then he joins the Masters of Evil and becomes a major Avengers villain. Along the way, he fathers Daisy Johnson, aka Quake. In this case, the apple falls relatively far from the tree, as Daisy becomes a SHIELD Agent and an Avenger.

Back to Mr. Hyde…He kind of bounces around for a time without really finding a place within the Marvel Universe, spending time in The Hood's gang and the Lethal Legion. He goes up against the Young Avengers, Moon Knight, and Ghost Rider, and then finally finds a completely unexpected place while imprisoned. He’s placed with the Thunderbolts B-Team and becomes stuck in time during a mission. But, hey, he gets a shot at being the actual Mr. Hyde in actual Victorian London for a while.