Source: newsarama.com

5. Venom

The only reason Eddie is this low on the list is that he's spent way more time as an anti-hero or straight-up superhero than he has as a villain. But he was a pretty terrifying villain at the beginning of his run.

Edward Brock was a journalist whose career was accidentally ruined when Spider-Man disproved his news article claiming to know the identity of the villainous Sin-Eater. Eddie had a crisis of faith and headed to church in the dead of night.

The same night, coincidentally, that Spider-Man was in the bell tower of that same church, ripping his new symbiote costume off his body. The symbiote found Brock, and the duo united in their hatred of Spider-Man. Venom appeared slowly in a trickle of comic book moments – slowly, but effectively, building up his presence.

He's vicious and tenacious, and really, REALLY hates Spider-Man. And he has an incredibly solid visual design.