My Super Ex-Girlfriend (2006)

Superhero movies are, in fact, a mix of genres. And My Super Ex-Girlfriend (starring the celestial body Uma Thurman) proves that very well, since it is in fact a romantic comedy. A guy (Luke Wilson) dumps his girlfriend because she is too needy – little does he know that she is in fact a superhero (called G-Girl), who got her powers when came into contact with a crashed meteorite.
It is probably the least well-received movie on this list, being called extremely sexist and misogynistic. However, it is still a hilarious take on the superhero genre, with a regular villain (Professor Bedlam, portrayed by Eddie Izzard) who wants to strip her. Of her powers, of course.
