Source: comicvine.gamespot.com

4. Shuma-Gorath

Hey, it's Shuma Gorath!! I know, like, nothing about Shuma Gorath.

And to be fair, a lot of that is because I'm not a classic Doctor Strange reader. So let's learn together. All I know about him was that he was in Marvel Vs. Capcom 2. Heck, until a few years ago, I'd assumed he was a Capcom character. He is traditionally one of the Old Ones or Many Angled Ones which are essentially Lovecraftian deities.

He's also a multiversal singularity because of this which means that there is only one version of him across all realities. Kill him and they all go poof. He picked several fights with Doctor Strange which makes sense. He's also in some space-based stuff though, specifically the Realm of Kings semi-crossover. In that, Quasar finds his way through the Fault into the Cancerverse, where the Many Angled Ones have infected and conquered earth's heroes, starting with Captain Mar-Vell. Shuma Gorath lost in the follow up event, The Thanos Imperative when Thanos tricked Death into coming to the Cancerverse.

Sorry about that one, Squid-Eye!