Source: youtube.com
7. The Lizard
Amazing Spider-Man (2012)
Woof.
I absolutely totally completely hate the visual design of this villain. He's maybe the worst looking Marvel villain in any movie. The classic comic book Lizard has a fang filled snout and a shredded lab coat. This one looks like Voldemort with a skin condition and ditches his clothes at the earliest opportunity. He looks more like the MCU Abomination than any actual Lizard. As well, he totally misses the point of including the Lizard in a film at all.
The Lizard is a haunted, tortured character. A brilliant scientist whose Jekyll and Hyde dynamic sees him transform into a bestial animal at the slightest provocation. The film simplifies this drastically, turning him into a boring madman who wants to turn everyone in New York into Lizards? For some odd reason?
I don't know, it's weird.

