Silvermane

With the Kingpin and Cottonmouth out of the equation, there aren’t that many major crime families active in New York. Taking into account the fact that the Punisher also eradicated or destabilized some other crime organizations, the Maggia family could pick up the leftovers during the Defenders.

Of course, in the comics Silvermane is a Spider-Man villain. Furthermore, he is a man. But it wouldn’t be the first time when Marvel gender-swapped a character when bringing it to life for the big or the small screen. As such, Silvermane could be an aging female on Netflix and she could be portrayed by Sigourney Weaver.

Yet again, this would be a physically demanding role for the actress, especially if the show has the villain enhanced like in the comics. But movie magic could make it work.

As said, Silvermane is a possibility, since he/she is a member of a crime family we haven’t seen just yet. But another reason would be that the character is known for going against new or up and coming heroes – and he does that in association with HYDRA.

So yes – Sigourney Weaver could bring this villain to life.