Ma Gnucci

A villain from Punisher’s rogues gallery, Ma Gnucci could become the main antagonist of the Defenders. Until now, the Netflix shows have featured quite a few baddies from New York crime families, such as Kingpin, Cottonmouth, Madame Gao, and others. Who is to say that the Defenders won't go the same route?

As such, Ma Gnucci would be the villain of the Defenders. However, since she is a Punisher villain, she could (and should) be kept alive for Frank Castle’s solo outing. In this way, the Punisher would sweep up after the Defenders have dismantled Ma Gnucci's network.

There are few chances that Sigourney Weaver will actually portray this villain. However, it wouldn't be the first time a character was adapted when introduced in the MCU. So, if this happens, Sigourney Weaver has the right presence for the role.

Who knows? Maybe she'll be mauled at the end of the Defenders and she'll come back with a vengeance during the Punisher's solo series.