Harley and the Joker

This is the most obvious choice and, thankfully, we will see this couple on the big screen. Yes, at times it will involve domestic violence, but no couple is perfect, after all.
This year's Suicide Squad won't just bring a new (and psychotic, for that matter) Joker, but also his twisted psychiatrist. And you are most obviously aware of how funny (and dark) this pair can be, especially when encountering the Batman.
Of course, it all depends on the writer, and how he or she can put the dark humor to good use. However, since Ben Affleck will write and direct the first solo Batman film, we trust that he will do a good job.
As far as Harley is concerned, we have already seen plenty of her comedic skills in the Suicide Squad trailers. All we need now is to see the Joker matching wits with her.
