3. Brainiac

This extraterrestrial android uses knowledge and intellect as his main weapon. He has a “12th-level intellect” that allows him to do things others cannot. In the first instance he was presented as being able to shrink cities and use them to renew his planet. The city of Kandor (capital city of Superman’s home planet) was a victim of his.

He has advanced understanding of various technologies that enable him to calculate abilities, possess others, absorb information from other beings, transfer his consciousness, create and manipulate computer systems, replicate multiple versions of himself, and exert powers to traverse or control space and time.

Brainiac is one of the most powerful supervillains Superman has faced and his presence is always a threat.