You can deduct mileage driven to medical appointments at 21 cents per mile (2024), plus parking and tolls. If you're managing a chronic condition or undergoing treatment across multiple locations, this adds up fast. A patient traveling 50 miles roundtrip for weekly therapy sessions could deduct over $500 annually. Keep a simple log in your car with dates and destinations. Many people forget this entirely, leaving legitimate deductions unclaimed year after year.