The Fountain (2006)

This one is a little tricky for this list as The Fountain originally started out as a Darren Aronofsky movie that had a ridiculous budget and Brad Pitt and Cate Blanchett lined up to star. For one reason or another, Brad Pitt dropped out of the film and the whole thing was shut down, permanently. Aronofsky totally freaked out and decided that if his crazy three part story of romantic partners trying to cheat death wasn't going to be made into a movie than he was going to have it as comic book. Once the comic book was complete, Warner Brothers turned around and offered to make the movie for half its original budget and starring Hugh Jackman and Rachel Weisz. Because of the strange order events, The Fountain rarely gets pegged as a comic book movie but despite its origins it is in fact one.