Through Sheer Willpower

The High Evolutionary started life as a mere human, but his intelligence was such that he was able to experiment on himself to make himself godlike in terms of his power levels.

In spite of the fact that he has indeed become a reality-warping god of epic proportions, the Marvel character’s most powerful weapon is still undoubtedly his intellect – and that means he has designed some pretty awesome and powerful devices and weapons in his time.

One of those devices was so powerful that, when activated, it mutated every living thing on the planet to become a more evolved being. However, Doctor Doom’s willpower is so incredibly strong that he was able to resist the mutation and best the High Evolutionary using the power of his mind alone.