4. Spider sense

Well, it is the spider sense of Spiderman that has saved him from a lot of trouble. However, it is also this early warning system that has led to his capture a lot of times. So, although the system is something that is part and parcel of becoming Spiderman, it also is not infallible. So, you could expect a lot of villains making use of this particular vulnerability in order to corner Spiderman, and make use of his responsiveness to danger as a method to track him.