The immortality

As we’ve mentioned, when becoming Deadpool, Wade Wilson didn’t heal his cancer – however, he received regenerative powers which, in a sense, dwarf those of Wolverine (who is the most well-known mutant to have these powers). Thus, this character can regenerate massive amounts of tissue – at times, he’s even donated his organs to those in need, simply because he’s able to regrow others.
For him, the sky is the limit – if his appendages or other body parts are detached, he just needs to place them back where they go. He’ll be good to go in no time at all.
But this isn’t all – while his powers are off the charts, the Weapon X program didn’t actually make him unkillable. Instead, it was all the Mad Titan’s doing. As everybody knows, Thanos loves Death (she is a female in the marvel comic book universe). He loves her so much that he was willing to kill the entire universe for her.
But the problem was that Death was infatuated with Deadpool (what skeleton wouldn’t be?). Thanos found that out and saw in the anti-hero a possible challenger for the (bony) hand of Death. So he cursed him with eternal life – in this way, Deadpool will never feel Death’s loving embrace. Sure, regeneration is an awesome ability – immortality is even better!
Deadpool killed the Marvel universe

Sure enough, Days of Future Past seems like the best way in which the Mutant Movie Universe can be rebooted. And Fox has done that, quite successfully, actually – thus now we have Deadpool and Gambit solo movies, as well as Apocalypse and X-Force movies down the pipe.
But another, and even more interesting, approach would be the adaptation (the key word is adaptation) of Deadpool Kills the Marvel Universe. The anti-hero is sent by the X-Men into a clinic to receive some much-needed therapy (yes, it is a clinic for mentally unstable people). But, unbeknownst to the X-Men, the doctor is secretly a villain who wants to further experiment on Deadpool (and this could be, for example, Mister Sinister in disguise). Deadpool catches on and kills him.
And then goes on a rampage, with the intention of killing all of the superheroes and supervillains in the universe. Why? Well, because he is insane. But an even better reason would be that the comic book writers are to be blamed for his condition (unf***able and bonkers), so he is out to kill everyone who could help the writers tell their stories.
Eventually, he does that and enters the real world, where he threatens the reader to come and get him. So much meta in here that our heads exploded. Speaking of which…
