3. Baron Zemo

The rumor is that one of Captain America's most feared villains will actually make an appearance in the Civil War adaptation "“ however, this might not be a major role (Daniel Brühl is rumored to have been cast in this role, although no official confirmation was made).

After the disappearance of Red Skull, this is one of the villains that could definitely take the role as a leader of HYDRA. Furthermore, since Zemo killed Bucky Barnes in the comics, his entry in the Civil War could be easily made.

2. Doctor Faustus

Well, not all the villains Captain America has clashed with were Nazis. Doctor Faustus only stayed with the Nazis because they had the most chances of taking over the world.

How come Faustus is so high on this list? Well, after all, despite not having any super powers, he is a master manipulator that had one of the most important roles in the death of Captain America"¦

1. Red Skull

Did you expect someone else? While Hugo Weaving said that he won't return, Red Skull is one of the most iconic villains in the MCU "“ even if this is also a character that wasn't explored to its full potential. Furthermore, we don't know whether he died or not "“ after all, the Tesseract is just a doorway.