Kill Himself

The heroes of the Marvel Cinematic Universe are going to have one hell of a tough time defeating Thanos with the Infinity Gauntlet once he gets his hands on all six Infinity Stones, but in the end they might not even need to.

There are two ways in which the Mad Titan might actually end up defeating himself. The first is that he might simply get careless and overload his body with the power of the Infinity Stones and the second is that, if Mistress Death is in the MCU and isn’t impressed by his actions, he might simply want to die and end up committing suicide using the six powerful items.

Unless Thanos is somehow tricked into taking the completed Infinity Gauntlet off, him killing himself seems like the only plausible way he could be defeated. The combined might of the likes of the Avengers and Guardians of the Galaxy is nowhere near enough to beat him in straight-up combat when he’s wielding the universe’s ultimate power, after all.